• Fasudil Hydrochloride CAS 105628-07-7
  • Fasudil Hydrochloride CAS 105628-07-7
  • Fasudil Hydrochloride CAS 105628-07-7
  • Fasudil Hydrochloride CAS 105628-07-7
  • Fasudil Hydrochloride CAS 105628-07-7
  • Fasudil Hydrochloride CAS 105628-07-7

Fasudil Hydrochloride CAS 105628-07-7

CAS No.: 105628-07-7
Formula: C14h18cln3o2s
EINECS: 805-833-0
Environmental Protection: Yes
Color: White
Appearance: Powder
Samples:
US$ 1/Piece 1 Piece(Min.Order)
| Request Sample
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Hubei, China
Importers and Exporters
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  • Overview
  • Product Description
  • Product Parameters
  • Company Profile
  • Certifications
  • FAQ
  • Our Advantages
  • Order Process and Tips
Overview

Basic Info.

Package
Foil Pouch/Paper Drum
Feature
White Power
Price
Negotiable
Sample
Yes
MOQ
Negotiable
Transport Package
as Request
Specification
as request
Origin
China
Production Capacity
1000000/Ton

Product Description

Fasudil hydrochloride;CAS 105628-07-7
 Fasudil Hydrochloride CAS 105628-07-7
 
Fasudil hydrochloride Chemical Properties
Melting point  220.5°; mp 219.3° (Shirotani)
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  H2O: >200 mg/mL
form  solid
color  white
Water Solubility  Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
Merck  14,3942
InChIKey LFVPBERIVUNMGV-UHFFFAOYSA-N
CAS DataBase Reference 105628-07-7(CAS DataBase Reference)
 
Safety Information
Risk Statements  22
Safety Statements  36-60
WGK Germany  3
RTECS  HM4031166
HS Code  29339900
Toxicity LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga)
 
Fasudil hydrochloride Usage And Synthesis
Indications and Usage Fasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
Mechanisms of Action Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.
Adverse reactions Adverse reactions after use can include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, and loss of consciousness, etc., as well as abnormal liver function. Low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever, etc. occur occasionally.
Warnings and Precautions Patients with intracranial hemorrhage or possibility thereof, or low blood pressure, should not use. Patients with diabetes mellitus, cerebral arterial sclerosis, severe disturbance of consciousness, subarachnoid hemorrhages with cerebrovascular disorders, and liver or kidney dysfunction, or those over 70 years old, pregnant, or children should use with caution. Breastfeeding women should stop while using the drug. Fasudil Hydrochloride can only be administered via intravenous drip.
Description Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.
Originator Asahi Chemical (Japan)
Uses vasodilator, potent Rho-kinase inhibitor
Brand name Marvel

Product Description

Fasudil Hydrochloride CAS 105628-07-7

Product Parameters


Fasudil Hydrochloride CAS 105628-07-7Fasudil Hydrochloride CAS 105628-07-7Fasudil Hydrochloride CAS 105628-07-7

Company Profile

Hubei Marvel Biopharmaceutical Co., Ltd. is located in Wuhan, Hubei Province, which is a water, land, and air transportation hub. It is a company dedicated to the development and sales of fine chemicals, pesticide raw materials, and other products.
The company is committed to developing into a powerful brand company with independent import and export management rights. Its innovative and breakthrough products not only make Marvel Pharmaceutical a leader in the industry domestically, but also enjoy a high reputation internationally. Always adhere to the business philosophy of "customer satisfaction and enterprise development", build a bridge with customers with the spirit of integrity and dedication, and serve customers better, faster, and more accurately.
The company has independent import and export management rights and an excellent sales team. With the diligent efforts of all employees, we have opened up a vast market for the company. The company's products sell well throughout the country and are exported to countries and regions such as Europe, America, Southeast Asia, and Africa. The number of customers served each year is over 2000, winning unanimous recognition and praise from our customers.
Fasudil Hydrochloride CAS 105628-07-7

 

Certifications

 

Fasudil Hydrochloride CAS 105628-07-7
 

FAQ


Q1: May I get one sample before placing order?
Re: Yes, Sample are available. For normal products, samples are for free and you just need to bear the freight; For those high value products, you just need to freight and certain product cost. When we both cooperate for some times or when you are our VIP customer, free sample will be offered when you need.

Q2: Which payment is available for your company?
Re: T/T, L/C or Alibaba trade insurance. You can choose the one which is convenient for you.

Q3: How and when can I get my goods after payment?
Re: For small quantity products, they will be delivered to you by international courier(DHL, FedEx, TNT etc.)
or by air. Usually it will cost 3-5days that you can get the goods after delivery.For large quantity products,
shipping by see is worthwhile.It will cost days to weeks to come to your destination port, which depends on
where the port is.

Q4: Is there any possible to use my appointed label or package?
Re: Yes. If needed, we'd like to use label or package according to your requirement.

Q5: How can you guarantee the goods you offer is qualified?
Re: We always believe honesty and responsibility are basis of one company, so whatever products we provide for you all are qualified. We will have goods tested and provide COA before delivery for sure.

Our Advantages

Advantages:
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
3. After-Sale Service: 
1)International Authorized Third-Party Test For The Products You Demand. 
2)60 Days Warranty of quality of goods.


 

Order Process and Tips

 

Make an order Please make clear what product and what quantity you need
Quote Prices and Specifications details would be offered for you to consider and confirm
Payment ways Bank Transfer, Western Union, Money Gram and Bitcoin
Delivery ways All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.)
Shipping address Provide your Valid and Correct destination address info(if possible with post code, phone number).
Packing Select best ways according to quantity and safety degree(Super discreet, professional and experienced)
Lead time Within 8 hours upon receipt of payment
Package picture Photos of package would be offered to tell apart the items
Tracking number Offered once it is released
Shipping time 3-7 working days (Door-to-Door)
After-sale service 24/7 Online for any problems




 


 

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Gold Member Since 2023

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Trading Company
Export Year
2024-05-06
Import & Export Mode
Have Own Export License